| Game Results | ||
| Teams | Date | Score |
| Minnesota at New Orleans | 9/9/2010 | MIN 36-33 |
| Atlanta at Pittsburgh | 9/12/2010 | PIA 16-13 |
| Carolina at New York (NFC) | 9/12/2010 | NYN 24-3 |
| Cincinnati at New England | 9/12/2010 | NEA 41-33 |
| Cleveland at Tampa Bay | 9/12/2010 | TBN 34-28 |
| Denver at Jacksonville | 9/12/2010 | DEA 38-32 |
| Indianapolis at Houston | 9/12/2010 | INA 41-13 |
| Miami at Buffalo | 9/12/2010 | MIA 41-16 |
| Oakland at Tennessee | 9/12/2010 | TNA 41-19 |
| Arizona at St. Louis | 9/12/2010 | SLN 33-10 |
| Green Bay at Philadelphia | 9/12/2010 | PHN 28-10 |
| San Francisco at Seattle | 9/12/2010 | SEN 24-13 |
| Dallas at Washington | 9/12/2010 | WAN 20-17 |
| Detroit at Chicago | 9/12/2010 | DEN 23-20 |
| Baltimore at New York (AFC) | 9/13/2010 | BAA 34-13 |
| San Diego at Kansas City | 9/13/2010 | SDA 41-21 |
| Arizona at Atlanta | 9/19/2010 | ATN 34-6 |
| Baltimore at Cincinnati | 9/19/2010 | BAA 17-6 |
| Buffalo at Green Bay | 9/19/2010 | GBN 58-0 |
| Chicago at Dallas | 9/19/2010 | CHN 25-17 |
| Kansas City at Cleveland | 9/19/2010 | CLA 34-13 |
| Miami at Minnesota | 9/19/2010 | MIN 28-27 |
| Pittsburgh at Tennessee | 9/19/2010 | PIA 34-7 |
| Tampa Bay at Carolina | 9/19/2010 | TBN 27-24 |
| Houston at Washington | 9/19/2010 | WAN 38-21 |
| Jacksonville at San Diego | 9/19/2010 | SDA 31-24 |
| New England at New York (AFC) | 9/19/2010 | NEA 30-15 |
| Seattle at Denver | 9/19/2010 | SEN 31-30 |
| St. Louis at Oakland | 9/19/2010 | OAA 41-22 |
| New York (NFC) at Indianapolis | 9/19/2010 | INA 30-27 |
| Philadelphia at Detroit | 9/19/2010 | PHN 24-10 |
| New Orleans at San Francisco | 9/20/2010 | SFN 28-24 |
| Atlanta at New Orleans | 9/26/2010 | NON 24-20 |
| Buffalo at New England | 9/26/2010 | NEA 23-15 |
| Cincinnati at Carolina | 9/26/2010 | CNA 27-13 |
| Cleveland at Baltimore | 9/26/2010 | CLA 24-10 |
| Dallas at Houston | 9/26/2010 | DAN 34-28 |
| Detroit at Minnesota | 9/26/2010 | MIN 40-9 |
| Pittsburgh at Tampa Bay | 9/26/2010 | PIA 27-7 |
| San Francisco at Kansas City | 9/26/2010 | KCA 51-25 |
| Tennessee at New York (NFC) | 9/26/2010 | NYN 31-7 |
| Indianapolis at Denver | 9/26/2010 | DEA 45-21 |
| Oakland at Arizona | 9/26/2010 | ARN 37-34 |
| Philadelphia at Jacksonville | 9/26/2010 | JXA 41-24 |
| San Diego at Seattle | 9/26/2010 | SDA 44-41 |
| Washington at St. Louis | 9/26/2010 | SLN 36-17 |
| New York (AFC) at Miami | 9/26/2010 | MIA 34-24 |
| Green Bay at Chicago | 9/27/2010 | CHN 23-17 |
| Baltimore at Pittsburgh | 10/3/2010 | BAA 30-24 |
| Carolina at New Orleans | 10/3/2010 | NON 24-17 |
| Cincinnati at Cleveland | 10/3/2010 | CLA 20-13 |
| Denver at Tennessee | 10/3/2010 | TNA 31-24 |
| Detroit at Green Bay | 10/3/2010 | DEN 20-17 |
| New York (AFC) at Buffalo | 10/3/2010 | NYA 13-10 |
| Seattle at St. Louis | 10/3/2010 | SEN 28-14 |
| San Francisco at Atlanta | 10/3/2010 | ATN 26-17 |
| Arizona at San Diego | 10/3/2010 | SDA 34-7 |
| Washington at Philadelphia | 10/3/2010 | PHN 34-28 |
| Houston at Oakland | 10/3/2010 | HOA 29-28 |
| Indianapolis at Jacksonville | 10/3/2010 | INA 29-17 |
| Chicago at New York (NFC) | 10/3/2010 | CHN 23-20 |
| New England at Miami | 10/4/2010 | NEA 32-26 |
| St. Louis at Detroit | 10/10/2010 | SLN 24-23 |
| New Orleans at Arizona | 10/10/2010 | NON 41-16 |
| San Diego at Oakland | 10/10/2010 | SDA 45-24 |
| Tennessee at Dallas | 10/10/2010 | DAN 33-27 |
| Green Bay at Washington | 10/10/2010 | GBN 30-10 |
| Tampa Bay at Cincinnati | 10/10/2010 | TBN 30-27 |
| Jacksonville at Buffalo | 10/10/2010 | BFA 28-16 |
| Kansas City at Indianapolis | 10/10/2010 | KCA 42-34 |
| Philadelphia at San Francisco | 10/10/2010 | PHN 20-17 |
| New York (NFC) at Houston | 10/10/2010 | NYN 31-20 |
| Atlanta at Cleveland | 10/10/2010 | ATN 23-20 |
| Chicago at Carolina | 10/10/2010 | CHN 31-14 |
| Denver at Baltimore | 10/10/2010 | DEA 34-17 |
| Minnesota at New York (AFC) | 10/11/2010 | MIN 20-14 |
| New York (AFC) at Denver | 10/17/2010 | NYA 34-28 |
| Dallas at Minnesota | 10/17/2010 | MIN 24-21 |
| Seattle at Chicago | 10/17/2010 | CHN 35-25 |
| New Orleans at Tampa Bay | 10/17/2010 | NON 27-24 |
| Miami at Green Bay | 10/17/2010 | GBN 34-20 |
| Kansas City at Houston | 10/17/2010 | KCA 35-28 |
| Detroit at New York (NFC) | 10/17/2010 | NYN 28-17 |
| Cleveland at Pittsburgh | 10/17/2010 | PIA 38-16 |
| Indianapolis at Washington | 10/17/2010 | INA 28-14 |
| Baltimore at New England | 10/17/2010 | BAA 24-17 |
| Atlanta at Philadelphia | 10/17/2010 | ATN 42-21 |
| San Diego at St. Louis | 10/17/2010 | SDA 20-16 |
| Oakland at San Francisco | 10/17/2010 | SFN 38-24 |
| Tennessee at Jacksonville | 10/18/2010 | JXA 24-14 |
| Buffalo at Baltimore | 10/24/2010 | BAA 47-14 |
| Cincinnati at Atlanta | 10/24/2010 | ATN 38-34 |
| Cleveland at New Orleans | 10/24/2010 | CLA 27-14 |
| Jacksonville at Kansas City | 10/24/2010 | KCA 21-20 |
| Philadelphia at Tennessee | 10/24/2010 | PHN 16-14 |
| Pittsburgh at Miami | 10/24/2010 | PIA 23-10 |
| San Francisco at Carolina | 10/24/2010 | SFN 18-12 |
| St. Louis at Tampa Bay | 10/24/2010 | TBN 34-31 |
| Washington at Chicago | 10/24/2010 | CHN 29-24 |
| Arizona at Seattle | 10/24/2010 | SEN 24-12 |
| New England at San Diego | 10/24/2010 | NEA 41-23 |
| Oakland at Denver | 10/24/2010 | OAA 37-13 |
| Minnesota at Green Bay | 10/24/2010 | GBN 35-13 |
| New York (NFC) at Dallas | 10/25/2010 | DAN 23-17 |
| Carolina at St. Louis | 10/31/2010 | SLN 40-28 |
| Pittsburgh at New Orleans | 10/31/2010 | PIA 34-29 |
| Tennessee at San Diego | 10/31/2010 | TNA 34-28 |
| Tampa Bay at Arizona | 10/31/2010 | ARN 38-16 |
| Seattle at Oakland | 10/31/2010 | OAA 31-28 |
| Minnesota at New England | 10/31/2010 | NEA 38-20 |
| Washington at Detroit | 10/31/2010 | DEN 27-21 |
| Miami at Cincinnati | 10/31/2010 | MIA 38-17 |
| Jacksonville at Dallas | 10/31/2010 | DAN 27-16 |
| Green Bay at New York (AFC) | 10/31/2010 | GBN 21-17 |
| Denver at San Francisco | 10/31/2010 | SFN 39-24 |
| Buffalo at Kansas City | 10/31/2010 | KCA 50-7 |
| Houston at Indianapolis | 11/1/2010 | INA 40-8 |
| Tampa Bay at Atlanta | 11/7/2010 | ATN 38-28 |
| New York (NFC) at Seattle | 11/7/2010 | NYN 23-14 |
| Miami at Baltimore | 11/7/2010 | MIA 30-27 |
| Dallas at Green Bay | 11/7/2010 | GBN 20-10 |
| New England at Cleveland | 11/7/2010 | NEA 24-17 |
| Arizona at Minnesota | 11/7/2010 | MIN 24-10 |
| Indianapolis at Philadelphia | 11/7/2010 | INA 45-31 |
| Kansas City at Oakland | 11/7/2010 | OAA 16-14 |
| Chicago at Buffalo | 11/7/2010 | CHN 38-19 |
| San Diego at Houston | 11/7/2010 | SDA 35-14 |
| New York (AFC) at Detroit | 11/7/2010 | DEN 30-7 |
| New Orleans at Carolina | 11/7/2010 | NON 41-17 |
| Pittsburgh at Cincinnati | 11/8/2010 | PIA 13-0 |
| Baltimore at Atlanta | 11/11/2010 | BAA 28-25 |
| Cincinnati at Indianapolis | 11/14/2010 | INA 20-17 |
| Detroit at Buffalo | 11/14/2010 | DEN 42-6 |
| Houston at Jacksonville | 11/14/2010 | HOA 34-20 |
| Minnesota at Chicago | 11/14/2010 | CHN 34-20 |
| New York (AFC) at Cleveland | 11/14/2010 | CLA 28-17 |
| Tennessee at Miami | 11/14/2010 | TNA 29-14 |
| Dallas at New York (NFC) | 11/14/2010 | DAN 21-17 |
| Kansas City at Denver | 11/14/2010 | KCA 20-17 |
| Seattle at Arizona | 11/14/2010 | ARN 36-34 |
| St. Louis at San Francisco | 11/14/2010 | SFN 27-24 |
| New England at Pittsburgh | 11/14/2010 | PIA 30-27 |
| Carolina at Tampa Bay | 11/14/2010 | TBN 38-17 |
| Philadelphia at Washington | 11/15/2010 | PHN 17-10 |
| Chicago at Miami | 11/18/2010 | CHN 20-6 |
| Arizona at Kansas City | 11/21/2010 | KCA 27-24 |
| New York (NFC) at Philadelphia | 11/21/2010 | PHN 27-10 |
| Tampa Bay at San Francisco | 11/21/2010 | TBN 26-23 |
| Seattle at New Orleans | 11/21/2010 | SEN 23-6 |
| Indianapolis at New England | 11/21/2010 | NEA 28-27 |
| Atlanta at St. Louis | 11/21/2010 | ATN 26-20 |
| Washington at Tennessee | 11/21/2010 | TNA 20-13 |
| Oakland at Pittsburgh | 11/21/2010 | PIA 29-9 |
| Houston at New York (AFC) | 11/21/2010 | HOA 45-31 |
| Green Bay at Minnesota | 11/21/2010 | GBN 34-17 |
| Detroit at Dallas | 11/21/2010 | DEN 26-10 |
| Cleveland at Jacksonville | 11/21/2010 | CLA 35-28 |
| Buffalo at Cincinnati | 11/21/2010 | CNA 34-7 |
| Baltimore at Carolina | 11/21/2010 | BAA 35-3 |
| Denver at San Diego | 11/22/2010 | SDA 27-6 |
| Cincinnati at New York (AFC) | 11/25/2010 | NYA 14-6 |
| New Orleans at Dallas | 11/25/2010 | DAN 26-14 |
| New England at Detroit | 11/25/2010 | NEA 23-7 |
| Tennessee at Houston | 11/28/2010 | HOA 33-31 |
| Pittsburgh at Buffalo | 11/28/2010 | PIA 26-23 |
| Minnesota at Washington | 11/28/2010 | WAN 27-21 |
| Jacksonville at New York (NFC) | 11/28/2010 | NYN 24-13 |
| Carolina at Cleveland | 11/28/2010 | CAN 17-10 |
| Green Bay at Atlanta | 11/28/2010 | GBN 38-17 |
| San Diego at Indianapolis | 11/28/2010 | SDA 31-24 |
| Tampa Bay at Baltimore | 11/28/2010 | BAA 34-10 |
| St. Louis at Denver | 11/28/2010 | SLN 38-35 |
| Philadelphia at Chicago | 11/28/2010 | PHN 30-3 |
| Miami at Oakland | 11/28/2010 | OAA 14-11 |
| Kansas City at Seattle | 11/28/2010 | KCA 25-20 |
| San Francisco at Arizona | 11/29/2010 | SFN 27-3 |
| Houston at Philadelphia | 12/2/2010 | PHN 34-17 |
| Buffalo at Minnesota | 12/5/2010 | MIN 38-10 |
| Chicago at Detroit | 12/5/2010 | DEN 23-17 |
| Cleveland at Miami | 12/5/2010 | CLA 16-13 |
| Denver at Kansas City | 12/5/2010 | KCA 38-31 |
| Jacksonville at Tennessee | 12/5/2010 | TNA 25-24 |
| New Orleans at Cincinnati | 12/5/2010 | CNA 27-20 |
| San Francisco at Green Bay | 12/5/2010 | GBN 17-3 |
| Washington at New York (NFC) | 12/5/2010 | NYN 35-27 |
| Atlanta at Tampa Bay | 12/5/2010 | ATN 37-31 |
| Carolina at Seattle | 12/5/2010 | SEN 24-10 |
| Dallas at Indianapolis | 12/5/2010 | INA 24-10 |
| Oakland at San Diego | 12/5/2010 | SDA 31-20 |
| St. Louis at Arizona | 12/5/2010 | SLN 27-14 |
| New York (AFC) at New England | 12/5/2010 | NEA 37-34 |
| Pittsburgh at Baltimore | 12/5/2010 | PIA 31-21 |