| League Schedule | |
| Week 1 | |
| Matchup | Date/Score |
|---|---|
| Minnesota at New Orleans | Minnesota wins 36-33 |
| Atlanta at Pittsburgh | Pittsburgh wins 16-13 |
| Carolina at New York (NFC) | New York (NFC) wins 24-3 |
| Cincinnati at New England | New England wins 41-33 |
| Cleveland at Tampa Bay | Tampa Bay wins 34-28 |
| Denver at Jacksonville | Denver wins 38-32 |
| Indianapolis at Houston | Indianapolis wins 41-13 |
| Miami at Buffalo | Miami wins 41-16 |
| Oakland at Tennessee | Tennessee wins 41-19 |
| Arizona at St. Louis | St. Louis wins 33-10 |
| Green Bay at Philadelphia | Philadelphia wins 28-10 |
| San Francisco at Seattle | Seattle wins 24-13 |
| Dallas at Washington | Washington wins 20-17 |
| Detroit at Chicago | Detroit wins 23-20 |
| Baltimore at New York (AFC) | Baltimore wins 34-13 |
| San Diego at Kansas City | San Diego wins 41-21 |
| Week 2 | |
| Matchup | Date/Score |
| Arizona at Atlanta | Atlanta wins 34-6 |
| Baltimore at Cincinnati | Baltimore wins 17-6 |
| Buffalo at Green Bay | Green Bay wins 58-0 |
| Chicago at Dallas | Chicago wins 25-17 |
| Kansas City at Cleveland | Cleveland wins 34-13 |
| Miami at Minnesota | Minnesota wins 28-27 |
| Pittsburgh at Tennessee | Pittsburgh wins 34-7 |
| Tampa Bay at Carolina | Tampa Bay wins 27-24 |
| Houston at Washington | Washington wins 38-21 |
| Jacksonville at San Diego | San Diego wins 31-24 |
| New England at New York (AFC) | New England wins 30-15 |
| Seattle at Denver | Seattle wins 31-30 |
| St. Louis at Oakland | Oakland wins 41-22 |
| New York (NFC) at Indianapolis | Indianapolis wins 30-27 |
| Philadelphia at Detroit | Philadelphia wins 24-10 |
| New Orleans at San Francisco | San Francisco wins 28-24 |
| Week 3 | |
| Matchup | Date/Score |
| Atlanta at New Orleans | New Orleans wins 24-20 |
| Buffalo at New England | New England wins 23-15 |
| Cincinnati at Carolina | Cincinnati wins 27-13 |
| Cleveland at Baltimore | Cleveland wins 24-10 |
| Dallas at Houston | Dallas wins 34-28 |
| Detroit at Minnesota | Minnesota wins 40-9 |
| Pittsburgh at Tampa Bay | Pittsburgh wins 27-7 |
| San Francisco at Kansas City | Kansas City wins 51-25 |
| Tennessee at New York (NFC) | New York (NFC) wins 31-7 |
| Indianapolis at Denver | Denver wins 45-21 |
| Oakland at Arizona | Arizona wins 37-34 |
| Philadelphia at Jacksonville | Jacksonville wins 41-24 |
| San Diego at Seattle | San Diego wins 44-41 |
| Washington at St. Louis | St. Louis wins 36-17 |
| New York (AFC) at Miami | Miami wins 34-24 |
| Green Bay at Chicago | Chicago wins 23-17 |
| Week 4 | |
| Matchup | Date/Score |
| Baltimore at Pittsburgh | Baltimore wins 30-24 |
| Carolina at New Orleans | New Orleans wins 24-17 |
| Cincinnati at Cleveland | Cleveland wins 20-13 |
| Denver at Tennessee | Tennessee wins 31-24 |
| Detroit at Green Bay | Detroit wins 20-17 |
| New York (AFC) at Buffalo | New York (AFC) wins 13-10 |
| Seattle at St. Louis | Seattle wins 28-14 |
| San Francisco at Atlanta | Atlanta wins 26-17 |
| Arizona at San Diego | San Diego wins 34-7 |
| Washington at Philadelphia | Philadelphia wins 34-28 |
| Houston at Oakland | Houston wins 29-28 |
| Indianapolis at Jacksonville | Indianapolis wins 29-17 |
| Chicago at New York (NFC) | Chicago wins 23-20 |
| New England at Miami | New England wins 32-26 |
| Week 5 | |
| Matchup | Date/Score |
| St. Louis at Detroit | St. Louis wins 24-23 |
| New Orleans at Arizona | New Orleans wins 41-16 |
| San Diego at Oakland | San Diego wins 45-24 |
| Tennessee at Dallas | Dallas wins 33-27 |
| Green Bay at Washington | Green Bay wins 30-10 |
| Tampa Bay at Cincinnati | Tampa Bay wins 30-27 |
| Jacksonville at Buffalo | Buffalo wins 28-16 |
| Kansas City at Indianapolis | Kansas City wins 42-34 |
| Philadelphia at San Francisco | Philadelphia wins 20-17 |
| New York (NFC) at Houston | New York (NFC) wins 31-20 |
| Atlanta at Cleveland | Atlanta wins 23-20 |
| Chicago at Carolina | Chicago wins 31-14 |
| Denver at Baltimore | Denver wins 34-17 |
| Minnesota at New York (AFC) | Minnesota wins 20-14 |
| Week 6 | |
| Matchup | Date/Score |
| New York (AFC) at Denver | New York (AFC) wins 34-28 |
| Dallas at Minnesota | Minnesota wins 24-21 |
| Seattle at Chicago | Chicago wins 35-25 |
| New Orleans at Tampa Bay | New Orleans wins 27-24 |
| Miami at Green Bay | Green Bay wins 34-20 |
| Kansas City at Houston | Kansas City wins 35-28 |
| Detroit at New York (NFC) | New York (NFC) wins 28-17 |
| Cleveland at Pittsburgh | Pittsburgh wins 38-16 |
| Indianapolis at Washington | Indianapolis wins 28-14 |
| Baltimore at New England | Baltimore wins 24-17 |
| Atlanta at Philadelphia | Atlanta wins 42-21 |
| San Diego at St. Louis | San Diego wins 20-16 |
| Oakland at San Francisco | San Francisco wins 38-24 |
| Tennessee at Jacksonville | Jacksonville wins 24-14 |
| Week 7 | |
| Matchup | Date/Score |
| Buffalo at Baltimore | Baltimore wins 47-14 |
| Cincinnati at Atlanta | Atlanta wins 38-34 |
| Cleveland at New Orleans | Cleveland wins 27-14 |
| Jacksonville at Kansas City | Kansas City wins 21-20 |
| Philadelphia at Tennessee | Philadelphia wins 16-14 |
| Pittsburgh at Miami | Pittsburgh wins 23-10 |
| San Francisco at Carolina | San Francisco wins 18-12 |
| St. Louis at Tampa Bay | Tampa Bay wins 34-31 |
| Washington at Chicago | Chicago wins 29-24 |
| Arizona at Seattle | Seattle wins 24-12 |
| New England at San Diego | New England wins 41-23 |
| Oakland at Denver | Oakland wins 37-13 |
| Minnesota at Green Bay | Green Bay wins 35-13 |
| New York (NFC) at Dallas | Dallas wins 23-17 |
| Week 8 | |
| Matchup | Date/Score |
| Carolina at St. Louis | St. Louis wins 40-28 |
| Pittsburgh at New Orleans | Pittsburgh wins 34-29 |
| Tennessee at San Diego | Tennessee wins 34-28 |
| Tampa Bay at Arizona | Arizona wins 38-16 |
| Seattle at Oakland | Oakland wins 31-28 |
| Minnesota at New England | New England wins 38-20 |
| Washington at Detroit | Detroit wins 27-21 |
| Miami at Cincinnati | Miami wins 38-17 |
| Jacksonville at Dallas | Dallas wins 27-16 |
| Green Bay at New York (AFC) | Green Bay wins 21-17 |
| Denver at San Francisco | San Francisco wins 39-24 |
| Buffalo at Kansas City | Kansas City wins 50-7 |
| Houston at Indianapolis | Indianapolis wins 40-8 |
| Week 9 | |
| Matchup | Date/Score |
| Tampa Bay at Atlanta | Atlanta wins 38-28 |
| New York (NFC) at Seattle | New York (NFC) wins 23-14 |
| Miami at Baltimore | Miami wins 30-27 |
| Dallas at Green Bay | Green Bay wins 20-10 |
| New England at Cleveland | New England wins 24-17 |
| Arizona at Minnesota | Minnesota wins 24-10 |
| Indianapolis at Philadelphia | Indianapolis wins 45-31 |
| Kansas City at Oakland | Oakland wins 16-14 |
| Chicago at Buffalo | Chicago wins 38-19 |
| San Diego at Houston | San Diego wins 35-14 |
| New York (AFC) at Detroit | Detroit wins 30-7 |
| New Orleans at Carolina | New Orleans wins 41-17 |
| Pittsburgh at Cincinnati | Pittsburgh wins 13-0 |
| Week 10 | |
| Matchup | Date/Score |
| Baltimore at Atlanta | Baltimore wins 28-25 |
| Cincinnati at Indianapolis | Indianapolis wins 20-17 |
| Detroit at Buffalo | Detroit wins 42-6 |
| Houston at Jacksonville | Houston wins 34-20 |
| Minnesota at Chicago | Chicago wins 34-20 |
| New York (AFC) at Cleveland | Cleveland wins 28-17 |
| Tennessee at Miami | Tennessee wins 29-14 |
| Dallas at New York (NFC) | Dallas wins 21-17 |
| Kansas City at Denver | Kansas City wins 20-17 |
| Seattle at Arizona | Arizona wins 36-34 |
| St. Louis at San Francisco | San Francisco wins 27-24 |
| New England at Pittsburgh | Pittsburgh wins 30-27 |
| Carolina at Tampa Bay | Tampa Bay wins 38-17 |
| Philadelphia at Washington | Philadelphia wins 17-10 |
| Week 11 | |
| Matchup | Date/Score |
| Chicago at Miami | Chicago wins 20-6 |
| Arizona at Kansas City | Kansas City wins 27-24 |
| New York (NFC) at Philadelphia | Philadelphia wins 27-10 |
| Tampa Bay at San Francisco | Tampa Bay wins 26-23 |
| Seattle at New Orleans | Seattle wins 23-6 |
| Indianapolis at New England | New England wins 28-27 |
| Atlanta at St. Louis | Atlanta wins 26-20 |
| Washington at Tennessee | Tennessee wins 20-13 |
| Oakland at Pittsburgh | Pittsburgh wins 29-9 |
| Houston at New York (AFC) | Houston wins 45-31 |
| Green Bay at Minnesota | Green Bay wins 34-17 |
| Detroit at Dallas | Detroit wins 26-10 |
| Cleveland at Jacksonville | Cleveland wins 35-28 |
| Buffalo at Cincinnati | Cincinnati wins 34-7 |
| Baltimore at Carolina | Baltimore wins 35-3 |
| Denver at San Diego | San Diego wins 27-6 |
| Week 12 | |
| Matchup | Date/Score |
| Cincinnati at New York (AFC) | New York (AFC) wins 14-6 |
| New Orleans at Dallas | Dallas wins 26-14 |
| New England at Detroit | New England wins 23-7 |
| Tennessee at Houston | Houston wins 33-31 |
| Pittsburgh at Buffalo | Pittsburgh wins 26-23 |
| Minnesota at Washington | Washington wins 27-21 |
| Jacksonville at New York (NFC) | New York (NFC) wins 24-13 |
| Carolina at Cleveland | Carolina wins 17-10 |
| Green Bay at Atlanta | Green Bay wins 38-17 |
| San Diego at Indianapolis | San Diego wins 31-24 |
| Tampa Bay at Baltimore | Baltimore wins 34-10 |
| St. Louis at Denver | St. Louis wins 38-35 |
| Philadelphia at Chicago | Philadelphia wins 30-3 |
| Miami at Oakland | Oakland wins 14-11 |
| Kansas City at Seattle | Kansas City wins 25-20 |
| San Francisco at Arizona | San Francisco wins 27-3 |
| Week 13 | |
| Matchup | Date/Score |
| Houston at Philadelphia | Philadelphia wins 34-17 |
| Buffalo at Minnesota | Minnesota wins 38-10 |
| Chicago at Detroit | Detroit wins 23-17 |
| Cleveland at Miami | Cleveland wins 16-13 |
| Denver at Kansas City | Kansas City wins 38-31 |
| Jacksonville at Tennessee | Tennessee wins 25-24 |
| New Orleans at Cincinnati | Cincinnati wins 27-20 |
| San Francisco at Green Bay | Green Bay wins 17-3 |
| Washington at New York (NFC) | New York (NFC) wins 35-27 |
| Atlanta at Tampa Bay | Atlanta wins 37-31 |
| Carolina at Seattle | Seattle wins 24-10 |
| Dallas at Indianapolis | Indianapolis wins 24-10 |
| Oakland at San Diego | San Diego wins 31-20 |
| St. Louis at Arizona | St. Louis wins 27-14 |
| New York (AFC) at New England | New England wins 37-34 |
| Pittsburgh at Baltimore | Pittsburgh wins 31-21 |
| Week 14 | |
| Matchup | Date/Score |
| Indianapolis at Tennessee | Manual |
| Atlanta at Carolina | Manual |
| Cincinnati at Pittsburgh | Manual |
| Cleveland at Buffalo | Manual |
| Green Bay at Detroit | Manual |
| Oakland at Jacksonville | Manual |
| Tampa Bay at Washington | Manual |
| Denver at Arizona | Manual |
| Kansas City at San Diego | Manual |
| Seattle at San Francisco | Manual |
| St. Louis at New Orleans | Manual |
| Philadelphia at Dallas | Manual |
| New England at Chicago | Manual |
| Miami at New York (AFC) | Manual |
| New York (NFC) at Minnesota | Manual |
| Baltimore at Houston | Manual |
| Week 15 | |
| Matchup | Date/Score |
| San Francisco at San Diego | 12/16/2010 |
| Kansas City at St. Louis | 12/19/2010 |
| New Orleans at Baltimore | 12/19/2010 |
| Green Bay at New England | 12/19/2010 |
| New York (AFC) at Pittsburgh | 12/19/2010 |
| Denver at Oakland | 12/19/2010 |
| Atlanta at Seattle | 12/19/2010 |
| Washington at Dallas | 12/19/2010 |
| Philadelphia at New York (NFC) | 12/19/2010 |
| Jacksonville at Indianapolis | 12/19/2010 |
| Houston at Tennessee | 12/19/2010 |
| Detroit at Tampa Bay | 12/19/2010 |
| Cleveland at Cincinnati | 12/19/2010 |
| Buffalo at Miami | 12/19/2010 |
| Arizona at Carolina | 12/19/2010 |
| Chicago at Minnesota | 12/20/2010 |
| Week 16 | |
| Matchup | Date/Score |
| Carolina at Pittsburgh | 12/23/2010 |
| Dallas at Arizona | 12/25/2010 |
| Houston at Denver | 12/26/2010 |
| Indianapolis at Oakland | 12/26/2010 |
| New York (NFC) at Green Bay | 12/26/2010 |
| San Diego at Cincinnati | 12/26/2010 |
| Seattle at Tampa Bay | 12/26/2010 |
| Baltimore at Cleveland | 12/26/2010 |
| Washington at Jacksonville | 12/26/2010 |
| San Francisco at St. Louis | 12/26/2010 |
| New York (AFC) at Chicago | 12/26/2010 |
| New England at Buffalo | 12/26/2010 |
| Detroit at Miami | 12/26/2010 |
| Tennessee at Kansas City | 12/26/2010 |
| New Orleans at Atlanta | 12/27/2010 |
| Minnesota at Philadelphia | 12/27/2010 |
| Week 17 | |
| Matchup | Date/Score |
| Buffalo at New York (AFC) | 1/2/2011 |
| Arizona at San Francisco | 1/2/2011 |
| Carolina at Atlanta | 1/2/2011 |
| Cincinnati at Baltimore | 1/2/2011 |
| Miami at New England | 1/2/2011 |
| Minnesota at Detroit | 1/2/2011 |
| Oakland at Kansas City | 1/2/2011 |
| Pittsburgh at Cleveland | 1/2/2011 |
| Tennessee at Indianapolis | 1/2/2011 |
| San Diego at Denver | 1/2/2011 |
| New York (NFC) at Washington | 1/2/2011 |
| Dallas at Philadelphia | 1/2/2011 |
| Chicago at Green Bay | 1/2/2011 |
| St. Louis at Seattle | 1/2/2011 |
| Tampa Bay at New Orleans | 1/2/2011 |
| Jacksonville at Houston | 1/2/2011 |