| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Peyton Manning - Indianapolis | Kansas City | 10/10/2010 | Kansas City 42-34 | 36 |
| Most Passing Yards | Peyton Manning - Indianapolis | Kansas City | 10/10/2010 | Kansas City 42-34 | 425 |
| Best Avg Yards Per Pass | Matt Hasselbeck - Seattle | San Diego | 9/26/2010 | San Diego 44-41 | 13.3 |
| Longest Completion | Michael Vick - Philadelphia | Houston | 12/2/2010 | Philadelphia 34-17 | 89 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Indianapolis | Kansas City | 10/10/2010 | Kansas City 42-34 | 36 |
| Most Passing Yards | Indianapolis | Kansas City | 10/10/2010 | Kansas City 42-34 | 425 |
| Best Avg Yards Per Pass | Seattle | San Diego | 9/26/2010 | San Diego 44-41 | 13.3 |
| Longest Completion | Philadelphia | Houston | 12/2/2010 | Philadelphia 34-17 | 89 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Adrian L. Peterson - Minnesota | New Orleans | 9/9/2010 | Minnesota 36-33 | 30 |
| Most Rushing Yards | LeGarrette Blount - Tampa Bay | Cincinnati | 10/10/2010 | Tampa Bay 30-27 | 226 |
| Best Rushing Avg | Michael Vick - Philadelphia | Jacksonville | 9/26/2010 | Jacksonville 41-24 | 15.3 |
| Longest Carry | Jerome Harrison - Philadelphia | Washington | 11/15/2010 | Philadelphia 17-10 | 68 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Minnesota | New Orleans | 9/9/2010 | Minnesota 36-33 | 50 |
| Most Rushing Yards | Philadelphia | Washington | 11/15/2010 | Philadelphia 17-10 | 286 |
| Best Rushing Avg | Tennessee | New York (NFC) | 9/26/2010 | New York (NFC) 31-7 | 11.8 |
| Longest Carry | Philadelphia | Washington | 11/15/2010 | Philadelphia 17-10 | 68 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Roddy White - Atlanta | Arizona | 9/19/2010 | Atlanta 34-6 | 14 |
| Most Receiving Yards | Vernon Davis - San Francisco | Denver | 10/31/2010 | San Francisco 39-24 | 246 |
| Best Reception Yardage Avg | Mike Wallace - Pittsburgh | New England | 11/14/2010 | Pittsburgh 30-27 | 32.2 |
| Longest Reception | DeSean Jackson - Philadelphia | Houston | 12/2/2010 | Philadelphia 34-17 | 89 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Indianapolis | Kansas City | 10/10/2010 | Kansas City 42-34 | 36 |
| Most Receiving Yards | Indianapolis | Kansas City | 10/10/2010 | Kansas City 42-34 | 425 |
| Best Reception Yardage Avg | Philadelphia | Houston | 12/2/2010 | Philadelphia 34-17 | 22.9 |
| Longest Reception | Philadelphia | Houston | 12/2/2010 | Philadelphia 34-17 | 89 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Stefan Logan - Detroit | Minnesota | 9/26/2010 | Minnesota 40-9 | 9 |
| Best Return Yardage Avg | Corey McIntyre - Buffalo | Minnesota | 12/5/2010 | Minnesota 38-10 | 69.0 |
| Longest Return | Ted Ginn Jr. - San Francisco | Kansas City | 9/26/2010 | Kansas City 51-25 | 102 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | San Francisco | Kansas City | 9/26/2010 | Kansas City 51-25 | 10 |
| Best Return Yardage Avg | Denver | Indianapolis | 9/26/2010 | Denver 45-21 | 64.0 |
| Longest Return | San Francisco | Kansas City | 9/26/2010 | Kansas City 51-25 | 102 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Captain Munnerlyn - Carolina | Cleveland | 11/28/2010 | Carolina 17-10 | 6 |
| Best Return Yardage Avg | Marc Mariani - Tennessee | Oakland | 9/12/2010 | Tennessee 41-19 | 82.0 |
| Longest Return | Marc Mariani - Tennessee | Oakland | 9/12/2010 | Tennessee 41-19 | 82 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Philadelphia | Tennessee | 10/24/2010 | Philadelphia 16-14 | 6 |
| Best Return Yardage Avg | Tennessee | Oakland | 9/12/2010 | Tennessee 41-19 | 82.0 |
| Longest Return | Tennessee | Oakland | 9/12/2010 | Tennessee 41-19 | 82 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Trevor Scott - Oakland | Seattle | 10/31/2010 | Oakland 31-28 | 18 |
| Sacks | Osi Umenyiora - New York (NFC) | Dallas | 11/14/2010 | Dallas 21-17 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Atlanta | Cleveland | 10/10/2010 | Atlanta 23-20 | 68 |
| Sacks | Oakland | St. Louis | 9/19/2010 | Oakland 41-22 | 8 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Shawntae Spencer - San Francisco | New Orleans | 9/20/2010 | San Francisco 28-24 | 3 |
| Best Interception Yardage Avg | Jairus Byrd - Buffalo | Baltimore | 10/24/2010 | Baltimore 47-14 | 98.0 |
| Longest Interception | Jairus Byrd - Buffalo | Baltimore | 10/24/2010 | Baltimore 47-14 | 98 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Green Bay | Miami | 10/17/2010 | Green Bay 34-20 | 6 |
| Best Interception Yardage Avg | Buffalo | Baltimore | 10/24/2010 | Baltimore 47-14 | 98.0 |
| Longest Interception | Buffalo | Baltimore | 10/24/2010 | Baltimore 47-14 | 98 |